It also decreases the production of nitric oxide, a compound that relaxes your lower esophageal sphincter, allowing stomach acid to enter your esophagus ( 20).įor this reason, some research suggests that melatonin may be used to treat heartburn and GERD. Melatonin has been shown to block the secretion of stomach acids. Gastroesophageal reflux disease (GERD) is a condition caused by the backflow of stomach acid into the esophagus, resulting in symptoms like heartburn, nausea and belching ( 19). One study found that melatonin capsules may help reduce symptoms, but other research is inconclusive. Seasonal depression may be related to changes in your body’s circadian rhythm. However, other research is still inconclusive on the effects of melatonin on seasonal depression.įor instance, another review of eight studies showed that melatonin was not effective at reducing symptoms of mood disorders, including bipolar disorder, depression and SAD ( 11).įurther research is needed to determine how melatonin may impact symptoms of seasonal depression. Some research indicates that it could be linked to changes in your circadian rhythm caused by seasonal light changes ( 10).īecause melatonin plays a role in regulating circadian rhythm, low doses are often used to decrease symptoms of seasonal depression.Īccording to one study in 68 people, alterations in circadian rhythm were shown to contribute to seasonal depression, but taking melatonin capsules daily was effective at reducing symptoms ( 5). This type of depression is related to changes in the seasons and occurs each year around the same time, with symptoms typically appearing in late fall to early winter. Seasonal affective disorder (SAD), also called seasonal depression, is a common condition that is estimated to affect up to 10% of the population worldwide ( 9). Could Reduce Symptoms of Seasonal Depression
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